Protein Sequencing by Expansion (ProSE™)

Protein Sequencing
by Expansion (ProSE™)
Advancing life science discovery with massively parallel, single-molecule 
proteome sequencing

Karan, Here is the 1st Option

1 TECHNOLOGY
ProSE™ will revolutionize proteomics by delivering unprecedented precision.
2025
[2. Expansion]
[3. Sequencing]
1

Sample Preparation

To prepare samples for ProSE, proteins and peptides are first functionalized by attaching an initiating linker to one terminus of each peptide chain.

2

Molecular Expansion

The functionalized peptides undergo a controlled expansion process, creating space between amino acids to ensure accurate detection during the sequencing phase.

3

Amino Acid Sequencing

Our proprietary sensors read the expanded molecule, identifying each amino acid with high precision to reconstruct the full protein sequence.

2nd Option

1 TECHNOLOGY
ProSE™ will revolutionize proteomics by delivering unprecedented precision.
2025
[2. Expansion]
[3. Sequencing]
1

Sample Preparation

To prepare samples for ProSE, proteins and peptides are first functionalized by attaching an initiating linker to one terminus of each peptide chain.

2

Molecular Expansion

The functionalized peptides undergo a controlled expansion process, creating space between amino acids to ensure accurate detection during the sequencing phase.

3

Amino Acid Sequencing

Our proprietary sensors read the expanded molecule, identifying each amino acid with high precision to reconstruct the full protein sequence.

Protein Sequencing by Expansion (ProSE™) leverages spatial expansion of amino acids from proteins to enable single amino acid discrimination of all 20 amino acids and PTMs.

Glyphic biotechnologies

Glyphic
Protein Structure
Biotechnologies
2 GLYPHIC BIOTECHNOLOGIES
Glyphic Biotechnologies, Inc. is developing the first truly de novo high-throughput proteome sequencing technology capable of discriminating all 20 AAs and PTMs accurately with single molecule sensitivity.
Since 2021
glyphic//bio

Protein Sequencing
by Expansion
(ProSE™)

Founded in 2021 and headquartered in Berkeley (CA), Glyphic Biotechnologies exists to fundamentally rewrite the rules of proteomics.

We believe proteome sequencing will be one of the defining technologies of the 21st century. The precision, scalability, and accessibility of Glyphic's Protein Sequencing by Expansion (ProSE™) will enable the development of critical first-in-class therapies, and deeper insights into life itself.

3

Our Blogs

At Glyphic Biotechnologies, we hire exceptional candidates motivated by solving complex, meaningful problems. Join our talented team in shaping the future of proteomics worldwide.

Contact

Contact

Information

A:

3100 San Pablo Ave. #201 Berkeley, CA 94702

S:

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